Lyme Center is an unincorporated village in the town of Lyme in Grafton County, New Hampshire, in the United States. It is located close to the geographic center of the town of Lyme, approximately 2 miles (3 km) east of New Hampshire Route 10 where it passes through the main village of Lyme.
Lyme Center has a separate ZIP code (03769) from the rest of the town of Lyme.